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KMID : 1007520090180030813
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Food Science and Biotechnology
2009 Volume.18 No. 3 p.813 ~ p.817
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Anti-inflammatory Mechanism of Seaweeds in Murine Macrophage
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Pan Cheol-Ho
Kim Eun-Sun
Um Byung-Hun
Lee Jae-Kwon
Kim Eun-Sun
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Abstract
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The effect of 4 seaweed extracts (Desmarestia viridis, Dictyopteris divaricata, Scytosiphon lomentaria, and Ishigeokamurae) on pro-inflammatory mediators as well as nuclear factor (NF)-κB in the stimulated Raw 264.7 cells wasinvestigated. They reduced iNOS and interlukin (IL)-1β expressions at transcription level. Of those, 3 extracts (D. divaricata,I. okamurae, and S. lomentaria) inhibited the COX-2 expression at translation level. IκB-α degradation was inhibited by D.divaricata and S. lomentaria extracts. Therefore, we concluded that the extracts from D. divaricata and S. lomentaria couldinhibit the activation of murine macrophage through the blocking of NF-κB activation.
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KEYWORD
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Desmarestia viridis, Dictyopteris divaricata, Scytosiphon lomentaria, Ishige okamurae, inducible nitric oxidesynthase (iNOS), interlukin-1β, cyclooxygenase (COX)-2, IκB, proinflammatory cytokine, anti-inflammation
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